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                                                             on Gopher (inofficial)
  HTML Visit Hacker News on the Web
       
       
       COMMENT PAGE FOR:
  HTML   Scientists unlock brain's natural clean-up system for new treatments for stroke
       
       
        bolangi wrote 56 min ago:
        Mainstream science has poo-poohed for years any notion that Oriental
        medicine practices for facilitating lymph flow have any utility. Nice
        to hear they're back on the allopathic table.
       
        Sparkyte wrote 3 hours 58 min ago:
        I love getting my lymph nodes drained. Feels so good afterward.
       
        spoaceman7777 wrote 7 hours 35 min ago:
        Yeah, the body-wide mucous thinning properties of NAC are one of the
        reasons it has racked up papers showing its efficacy in a truly
        staggering number of illnesses and conditions. (Including
        neurodegenerative diseases.)
        
        Highly recommend reading the actual literature on its effects in regard
        to cystic fibrosis, pancreatitis, COPD, neurodegenerative disorders,
        high blood pressure, ulcers, IBD, liver and kidney problems, OCD...
        
        The list goes on at a pretty extreme length, and it sounds too good to
        be true, but the papers are out there.
       
          flowerthoughts wrote 2 hours 41 min ago:
          I can't find anything in the article about NAC or N-acetylcystein.
          What's the relevance?
       
            spoaceman7777 wrote 2 hours 29 min ago:
            The article is about improving the flow of lymph in the brain, and
            NAC thins mucous, lymph, and various other bodily fluids, which
            leads to improved flow and general clearance.
       
          Aurornis wrote 4 hours 17 min ago:
          NAC is in the category of supplements  that sound unbelievably
          amazing on paper, but are frequently discontinued by people trying to
          take it long term. Some people seem to like it, but it’s common for
          people to take it for a while and realize it’s causing side effects
          like anhedonia, apathy, minor sleep disruptions, or other subtle
          negative effects. Not everyone, but it’s a common outcome.
          
          It also doesn’t quite live up to a lot of the incredible sounding
          papers for many conditions. It’s really common to find papers or
          even small trials purporting to find amazing effects from supplements
          that fail to replicate at scale. NAC does have some legitimate
          applications and is even used medically for certain conditions. I’m
          a little more skeptical that all of the amazing positives for every
          condition under the sun will hold up.
       
            itchyouch wrote 3 hours 19 min ago:
            When considering NAC's mechanisms, it seems that it's efficacy is
            likely dependent on an individuals's glutathione status.
            
            I doubt that folks with a solid diet, high in sulfur would find
            much benefit from NAC.
            
            However, as someone who's gotten to use it first hand and have
            dealt with lifelong, mild inflammation (puffy fingers, clogged nose
            here and there), it's definitely been a huge quality of life
            enhancer.
       
          Trasmatta wrote 4 hours 26 min ago:
          It's also very effective at helping reduce the damage of alcohol, if
          you take it before drinking. Lessens hangovers too.
       
            n8henrie wrote 4 hours 22 min ago:
            Citation?
       
          AnthonBerg wrote 7 hours 8 min ago:
          Seconded.
          
          I... I don't know how to get it across; For the love of God read the
          literature on NAC, alpha lipoic acid, bromhexine, and ambroxol.
          
          Just... read. Read the molecular biology papers.
       
            vixen99 wrote 38 min ago:
            Or browse these;
            
  HTML      [1]: https://www.freefullpdf.com/search_gcse/?q=NAC#gsc.tab=0&g...
       
            TripleTree wrote 3 hours 57 min ago:
            Where would you recommend?
       
            p1esk wrote 5 hours 38 min ago:
            Would regular engineers like us understand molecular biology
            papers?
       
              DANmode wrote 3 hours 36 min ago:
              You’ll understand the abstract and the conclusion!
              
              :eyeroll:
       
                p1esk wrote 3 hours 10 min ago:
                OK, I just read the abstract and conclusion of the NAC paper
                posted above. But then I saw a comment from Aurornis saying
                it’s not that good. Not sure who I should listen to.
       
          ridgeguy wrote 7 hours 11 min ago:
          Can you suggest a review article or two? Interested in this as my dad
          passed from hemorrhagic stroke, my mom from occlusive stroke. Thanks.
       
            Loughla wrote 6 hours 37 min ago:
            Would also like to ask for a starting point in this. Googling has
            not really gotten me anywhere credible. Specifically related to
            stroke or high blood pressure (both family traits).
       
              refibrillator wrote 4 hours 17 min ago:
              Here’s a starting point: [1] TLDR: NAC is a derivative of an
              amino acid called cysteine, as such it is a precursor for one of
              the most important antioxidants in the body and it can modulate
              key metabolic pathways associated with good health across a
              variety of organs, notably for decades it has been a universally
              successful antidote for acetaminophen (Tylenol) overdose, it’s
              available over the counter but NAC is not naturally found in
              foods, eating cysteine-rich foods like chicken turkey yogurt etc
              is the next best bet.
              
  HTML        [1]: https://pmc.ncbi.nlm.nih.gov/articles/PMC5241507/#B1
       
        lanakei wrote 8 hours 43 min ago:
        Full article:
        
  HTML  [1]: https://www.monash.edu/news/articles/scientists-unlock-brains-...
       
        canadiantim wrote 9 hours 23 min ago:
        Very interesting, especially in light of the Chinese study’s claiming
        to have success with a large subset of Alzheimer’s by adding a shunt
        to the cervical lymphatic nodes, which seems to be exactly what
        they’re doing here too.
        
        For those who don’t want to wait and have someone they love who can
        benefit from this, simply massaging the lymph nodes in the neck 10
        minutes a day also significantly increases flow through these lymph
        nodes and thereby increases drainage of lymph from the brain.
       
          agumonkey wrote 3 hours 27 min ago:
          Makes me wonder if body posture promoting blood flow to the head
          (yoga or else) can be helpful here too.
       
            gehwartzen wrote 1 hour 0 min ago:
            I like hanging upside down which seems to get a lot of fluid flow
            to the brain. Using ankle hooks and an electric hoist or just
            hanging by the back of the knees over a bar.
       
          rowanG077 wrote 7 hours 57 min ago:
          Is this something I can do to myself? Is there some kind of video
          tutorial to see what I really need to do?
       
            lemonberry wrote 3 hours 58 min ago:
            Andrew Huberman did an episode in October on the lymphatic system.
            I learned a lot. Highly recommend.
       
            drekk wrote 7 hours 20 min ago:
            You absolutely can! Look up "lymphatic face drainage" on YouTube,
            there are lots of tutorials. You can do it with just your hands or
            a jade gua sha tool.
       
              femto wrote 4 hours 56 min ago:
              I wonder if anyone has ever done a study to see if there is a
              correlation between daily wet facial shaving with soap and
              Alzheimer's?  A wet shave would be a short facial massage, whilst
              lathering the shaving soap.
       
              Loughla wrote 6 hours 36 min ago:
              Other than maybe helping with Alzheimer's as claimed above, is
              there any benefit to this?
       
          yosito wrote 8 hours 10 min ago:
          It would be really interesting if we find out that a simple 10 minute
          daily massage of the lymph nodes in the neck significantly prevents
          Alzheimer's.
       
            crossroadsguy wrote 7 hours 39 min ago:
            .. and I think there are already evidence that it tends to affect
            people who had regular lymphatic inflammations throughout their
            life (on a less serious note: like yours truly's.. the neck/throat
            ones.. and I am already forgetting things and blanking out and I
            haven't even touched 40 :/).
       
          colordrops wrote 9 hours 0 min ago:
          Hmm, I had a bunch removed due to thyroid cancer. I wonder if that
          reduced my brains ability to clean itself out.
       
            monero-xmr wrote 8 hours 33 min ago:
            It will turn out we just need to sit in a box for 15 minutes a day
            to pound us with magnets, sound waves, and hardcore vibrations to
            live to 125
       
              bsder wrote 7 hours 53 min ago:
              Heavy metal stops Alzheimer's!    Yeah!  \m/_(>_<)_\m/
              
              Huh?  What did you say?  You'll have to speak up louder, though.
       
              calvinmorrison wrote 7 hours 56 min ago:
              also living on 600 calories a day of course
       
              hkt wrote 8 hours 24 min ago:
              Don't forget near infrared lasers for some photobiomodulation!
       
                dmd wrote 7 hours 55 min ago:
                supposing you brought the light inside the body, either through
                the skin or some other way
       
       
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