Subj : Brain Implants, AI Enzyme
To   : All
From : Mike Powell
Date : Sat Feb 15 2025 09:56:00

From TLDR 2025-02-14

 BRAIN IMPLANT THAT COULD BOOST MOOD BY USING ULTRASOUND TO GO UNDER
NHS TRIAL (3 MINUTE READ) [6] 

 The UK's Advanced Research and Intervention Agency (Aria) is funding
a trial to test a brain-computer interface that directly alters brain
activity using ultrasound to boost mood. The technology could
revolutionize the treatment of conditions such as depression,
addiction, OCD, and epilepsy by rebalancing disrupted patterns of
brain activity. The device was developed by a US-based non-profit
called Forest Neurotech. The trial will recruit patients who have had
a part of their skull temporarily removed so that the device can be
tested without having to perform surgery. It will run for three and a
half years starting in March, and if successful, the device will move
into full clinical trials. 

 AI-DESIGNED ENZYMES (7 MINUTE READ) [8] 

 One of the ultimate aims of protein design is to build entirely new
enzymes from scratch. Scientists have traditionally discovered enzymes
in nature and then adapted them through trial and error. New advances
in AI may eventually lead to ways to create bespoke enzymes from the
ground up, but doing so remains a formidable challenge. Many of the
protein structural databases used to train models consist
overwhelmingly of structures gleaned from 'frozen' images, preventing
them from making accurate recreations of dynamic structures. 

 AI IS STIFLING TECH ADOPTION (6 MINUTE READ) [12] 

 The integration of AI has stifled the adoption of new and potentially
superior technologies due to training data cutoffs and system prompt
influence. 

 OPEN SOURCE SOFTWARE AND CORPORATE INFLUENCE (34 MINUTE READ) [13] 

 The large-scale engagement of corporations in open source needs to be
treated seriously because it has and will continue to have negative
consequences even if every individual involved is participating in
good faith. 

 META CTO SAYS STAFF SHOULD QUIT IF THEY DON'T LIKE META'S NEW
POLICIES (1 MINUTE READ) [14] 

 Meta CTO Andrew Bosworth said employees were free to quit if they
think that it's okay to leak to the media because of policy disagreements.

 AI OR DIE (7 MINUTE READ) [16] 

 It may be possible to have 'a country of geniuses' within a data
center by as early as 2026 - companies will need to be prepared for
this future. 

Links:
------
[6] https://www.theguardian.com/science/2025/jan/20/brain-implant-boost-mood-ul
trasound-nhs-trial?utm_source=tldrnewsletter
[8] https://press.asimov.com/articles/ai-enzymes?utm_source=tldrnewsletter
[12]
https://vale.rocks/posts/ai-is-stifling-tech-adoption?utm_source=tldrnewsletter
[13] https://www.alilleybrinker.com/blog/open-source-software-and-corporate-inf
luence/?utm_source=tldrnewsletter
[14] https://techcrunch.com/2025/02/13/meta-cto-says-staff-should-quit-if-they-
dont-like-metas-new-policies/?utm_source=tldrnewsletter
[16] https://www.rkg.blog/ai-or-die.php?utm_source=tldrnewsletter

 --  https://tldr.tech

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