Subj : Holograms for life: Improving IVF succes To : All From : ScienceDaily Date : Wed Jul 05 2023 22:30:22 Holograms for life: Improving IVF success Date: July 5, 2023 Source: University of Adelaide Summary: In a world-first, 3D holographic images of an embryo have been developed. The images are created using minuscule amounts of light in a fraction of a second. Facebook Twitter Pinterest LinkedIN Email ========================================================================== FULL STORY ========================================================================== In a world-first, 3D holographic images of an embryo have been developed as part of a collaborative research project between the University of Adelaide and University of St Andrews. The images are created using miniscule amounts of light in a fraction of a second. The team, led by Dr Kylie Dunning, Hospital Research Foundation fellow from the University of Adelaide's Robinson Research Institute, and Professor Kishan Dholakia from the University of Adelaide and the University of St Andrews, developed an approach to create 3D holographic images of the pre-clinical model of an embryo at various stages of development. "For couples wishing to conceive, the quality, or developmental potential, of an embryo is critical as it dictates the success of their pregnancy and ultimately, the birth of their child," said Dr Dunning. "In vitro fertilisation (IVF) clinics routinely assess embryo quality by visual inspection to check if an embryo is developing in a time-appropriate manner or by an invasive biopsy to determine DNA content of the biopsied sample. "However, these approaches have failed to improve the success rate of IVF which has remained stagnant for more than a decade." A non-invasive approach without biopsy to help pick the most appropriate embryo is a highly beneficial tool for the 21st century embryologist: light can fulfill this need. 3D holographic images are a non-invasive approach which provides insights into the embryo by identifying detailed features. This may augment conventional visual assessment for embryo quality in an IVF clinic, allowing an embryologist to make an informed decision on the selection of best quality embryos. "Optical technologies hold immense promise to unravel the metabolism and health of the embryo. This gentle, non-invasive approach could lead to improved IVF success," said Dr Dunning. Data from 2020 show that the success rates of IVF range from a live birth rate of 38.9 per cent per embryo transfer for patients under 34 years, to a live birth rate of 5.6 per cent per embryo transfer for patients over 43 years. In 2018 it was estimated that eight million babies had been born through IVF since the world's first in 1978. "This technology uses minuscule amounts of light -- less than that from your smartphone -- to allow rapid visualisation of the embryo in a fraction of a second," said Professor Dholakia. "It's a prime example of interdisciplinary success for our new Centre of Light for Life at the University of Adelaide, and of collaborative international work with my group at the University of St Andrews, Scotland." The team aims to have the technology, which is being developed through research using a preclinical model, available in five years. This cutting-edge development would not have been possible without the support of funding from the UK and EU, and the Australian Research Council (ARC), National Health and Medical Research Council and the Hospital Research Foundation in Australia. Primary authors on the study are George Dwapanyin, postdoctoral researcher at the University of St Andrews and Darren Chow, PhD candidate at the Robinson Research Institute, School of Biomedicine, University of Adelaide. * RELATED_TOPICS o Health_&_Medicine # Pregnancy_and_Childbirth # Birth_Defects # Fertility # Today's_Healthcare o Matter_&_Energy # Optics # Medical_Technology # Engineering # Forensic_Research * RELATED_TERMS o Confocal_laser_scanning_microscopy o Scanning_electron_microscope o Eye o Bone_scan o Interventional_radiology o Radiography o Myopia o CAT_scan ========================================================================== Print Email Share ========================================================================== ****** 1 ****** ***** 2 ***** **** 3 **** *** 4 *** ** 5 ** Breaking this hour ========================================================================== * Why_Birds_Ancestors_Lived;_Other_Dinosaurs_Died * Dissolving_Cardiac_Device_Treats_Heart_Disease * Webb_Locates_Dust_Reservoirs_in_Two_Supernovae * Earth_Formed_from_Dry,_Rocky_Building_Blocks * Ancient_Volcanic_Activity_On_Moon's_Dark_Side * Highly_Conductive_Metallic_Gel_for_3D_Printing * Potent_Greenhouse_Gas_Could_Be_Abated_Today * Polymer_Brains_for_Artificial_Neural_Networks * Early_Apex_Predator_Sought_Soft_Over_... * Time_in_Universe_Once_Flowed_Five_Times_Slower Trending Topics this week ========================================================================== HEALTH_&_MEDICINE Fitness Genes Cholesterol MIND_&_BRAIN Child_Psychology Creativity Educational_Psychology LIVING_&_WELL Fitness Healthy_Aging Staying_Healthy ========================================================================== Strange & Offbeat ========================================================================== HEALTH_&_MEDICINE Grocery_Store_Carts_Set_to_Help_Diagnose_Common_Heart_Rhythm_Disorder_and Prevent_Stroke DNA_Can_Fold_Into_Complex_Shapes_to_Execute_New_Functions Everyone's_Brain_Has_a_Pain_Fingerprint_--_New_Research_Has_Revealed_for_the First_Time MIND_&_BRAIN AI_Tests_Into_Top_1%_for_Original_Creative_Thinking Scientists_Discover_Spiral-Shaped_Signals_That_Organize_Brain_Activity Illusions_Are_in_the_Eye,_Not_the_Mind LIVING_&_WELL AI_Tests_Into_Top_1%_for_Original_Creative_Thinking Amputees_Feel_Warmth_in_Their_Missing_Hand Why_Do_Champagne_Bubbles_Rise_the_Way_They_Do?_Scientists'_New_Discovery_Is Worthy_of_a_Toast Story Source: Materials provided by University_of_Adelaide. Original written by Jessica Stanley. Note: Content may be edited for style and length. ========================================================================== Journal Reference: 1. George O. Dwapanyin, Darren J. X. Chow, Tiffany C. Y. Tan, Nicolas S. Dubost, Josephine M. Morizet, Kylie R. Dunning, Kishan Dholakia. Investigation of refractive index dynamics during in vitro embryo development using off-axis digital holographic microscopy. Biomedical Optics Express, 2023; 14 (7): 3327 DOI: 10.1364/BOE.492292 ========================================================================== Link to news story: https://www.sciencedaily.com/releases/2023/07/230705194525.htm --- up 1 year, 18 weeks, 2 days, 10 hours, 50 minutes * Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3) .