Subj : Fluctuating levels of cholesterol and tr To : All From : ScienceDaily Date : Wed Jul 05 2023 22:30:22 Fluctuating levels of cholesterol and triglycerides linked to increased risk of dementia Date: July 5, 2023 Source: American Academy of Neurology Summary: Older people who have fluctuating levels of cholesterol and triglycerides may have a higher risk of Alzheimer's disease and related dementias compared to people who have steady levels, according to new research. While the study found a link, it does not prove that fluctuating levels of cholesterol and triglycerides cause dementia. Facebook Twitter Pinterest LinkedIN Email ========================================================================== FULL STORY ========================================================================== Older people who have fluctuating levels of cholesterol and triglycerides may have a higher risk of Alzheimer's disease and related dementias compared to people who have steady levels, according to new research published in the July 5, 2023, online issue of Neurology(R), the medical journal of the American Academy of Neurology. While the study found a link, it does not prove that fluctuating levels of cholesterol and triglycerides cause dementia. "Prevention strategies for Alzheimer's and related dementias are urgently needed," said study author Suzette J. Bielinski, PhD, of the Mayo Clinic in Rochester, Minnesota. "Routine screenings for cholesterol and triglyceride levels are commonly done as part of standard medical care. Fluctuations in these results over time could potentially help us identify who is at greater risk for dementia, help us understand mechanisms for the development of dementia and ultimately determine whether leveling out these fluctuations could play a role in reducing dementia risk." Researchers used health care data to identify 11,571 people age 60 or older who did not have a prior diagnosis of Alzheimer's disease or dementia. Researchers looked at participants' measurements of total cholesterol, triglycerides, low- density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL) on at least three different days in the five years before the start of the study. Then researchers divided participants into five equal groups based on how much the measurements fluctuated. The lowest group had the least variation over time and the highest group had the most variation. Participants were followed for an average of 13 years. During that time, 2,473 people developed Alzheimer's disease or another form of dementia. After adjusting for variables that could affect risk of dementia including sex, race, education and lipid-lowering treatments, researchers found for total cholesterol, participants in the highest group had a 19% increased risk of dementia compared to those in the lowest group. Of the 2,311 people in the highest group, 515 developed dementia compared to 483 of the 2,311 people in the lowest group. For triglycerides, those in highest group had a 23% increased risk. Researchers did not find a link between variations in LDL and HDL and an increased risk of dementia. "It remains unclear why and how fluctuating levels of cholesterol and triglycerides are related to the risk of Alzheimer's disease," said Bielinski. "Further studies looking at the changes over time for this relationship are needed in order to confirm our results and potentially consider preventative strategies." A limitation of the study was researchers looked at Alzheimer's disease and related dementias as a whole and did not differentiate between the types of dementia. The study was supported by the National Heart, Lung and Blood Institute. * RELATED_TOPICS o Health_&_Medicine # Cholesterol # Alzheimer's_Research # Triglycerides # Healthy_Aging o Mind_&_Brain # Alzheimer's # Dementia # Disorders_and_Syndromes # Caregiving * RELATED_TERMS o Cholesterol o Dementia_with_Lewy_bodies o Low_density_lipoprotein o Facial_symmetry o Hypercholesterolemia o Alzheimer's_disease o Excitotoxicity_and_cell_damage o High_density_lipoprotein ========================================================================== Print Email Share ========================================================================== ****** 1 ****** ***** 2 ***** **** 3 **** *** 4 *** ** 5 ** Breaking this hour ========================================================================== * Why_Birds_Ancestors_Lived;_Other_Dinosaurs_Died * Dissolving_Cardiac_Device_Treats_Heart_Disease * Webb_Locates_Dust_Reservoirs_in_Two_Supernovae * Earth_Formed_from_Dry,_Rocky_Building_Blocks * Ancient_Volcanic_Activity_On_Moon's_Dark_Side * Highly_Conductive_Metallic_Gel_for_3D_Printing * Potent_Greenhouse_Gas_Could_Be_Abated_Today * Polymer_Brains_for_Artificial_Neural_Networks * Early_Apex_Predator_Sought_Soft_Over_... * Time_in_Universe_Once_Flowed_Five_Times_Slower Trending Topics this week ========================================================================== HEALTH_&_MEDICINE Fitness Genes Cholesterol MIND_&_BRAIN Child_Psychology Creativity Educational_Psychology LIVING_&_WELL Fitness Healthy_Aging Staying_Healthy ========================================================================== Strange & Offbeat ========================================================================== HEALTH_&_MEDICINE Grocery_Store_Carts_Set_to_Help_Diagnose_Common_Heart_Rhythm_Disorder_and Prevent_Stroke DNA_Can_Fold_Into_Complex_Shapes_to_Execute_New_Functions Everyone's_Brain_Has_a_Pain_Fingerprint_--_New_Research_Has_Revealed_for_the First_Time MIND_&_BRAIN AI_Tests_Into_Top_1%_for_Original_Creative_Thinking Scientists_Discover_Spiral-Shaped_Signals_That_Organize_Brain_Activity Illusions_Are_in_the_Eye,_Not_the_Mind LIVING_&_WELL AI_Tests_Into_Top_1%_for_Original_Creative_Thinking Amputees_Feel_Warmth_in_Their_Missing_Hand Why_Do_Champagne_Bubbles_Rise_the_Way_They_Do?_Scientists'_New_Discovery_Is Worthy_of_a_Toast Story Source: Materials provided by American_Academy_of_Neurology. Note: Content may be edited for style and length. ========================================================================== Journal Reference: 1. Ethan D. Moser, Sheila M. Manemann, Nicholas B. Larson, Jennifer L. St. Sauver, Paul Y. Takahashi, Michelle M. Mielke, Walter A. Rocca, Janet E. Olson, Ve'ronique L. Roger, Alan T. Remaley, Paul A. Decker, Jill M. Killian, Suzette J. Bielinski. Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease Related Dementias. Neurology, 2023; DOI: 10.1212/ WNL.0000000000207595 ========================================================================== Link to news story: https://www.sciencedaily.com/releases/2023/07/230705171104.htm --- up 1 year, 18 weeks, 2 days, 10 hours, 50 minutes * Origin: -=> Castle Rock BBS <=- Now Husky HPT Powered! (1:317/3) .